Thursday, October 30, 2014 7:10:04 PM
ittle or no
pharmacological effect, may become dangerous in the presence of
an MAO inhibitor and cause headache, stiff neck, cardiovascular
difficulties, and even death. MAO inhibitors may intensify and
prolong the effects of other drugs (CNS depressants, narcotic
analgesics, anticholinergics, dibenzazepine antidepressants,
etc.) by interfering with their metabolism. In the presence of an
MAO inhibitor many substances which are ordinarily non-active
because of their swift metabolism may become potent psychoactive
drugs. The phenomenon may create a new series of mind alterants.
file:///C|/Documents%20and%20Settings/All%20Users/...0Culture/Ayahuasca%20and%20DMT/DMT%20FAQ%202.0.txt (4 of 13)4/14/2004 9:11:34 PM
However, because of the complex and precarious variables
involved, it is risky and foolish for anyone to experiment with
these possibilities on the non-professional level.
The most commonly used MAO inhibitors include hydrazines
such as iproniazid, Marsilid, Marplan, Niamid, Nardil, Catron;
also non-hydrazines such as propargylamines, cyclopropylamines,
aminopyrazine derivatives, indolealkylamines, and
carbolines. MAO-inhibiting materials discussed in this book
include yohimbine, various tryptamines, especially 5-MeO-DMT and
the methyltryptamines, and the various harmala alkaloids. The
latter are especially potent inhibitors but, like yohimbine and
the trytamines, are short)lasting in action (30 minutes to
several hours). Some of the commercial MAO inhibitors listed
above are effective for several days to several weeks.
Among the materials which may be dangerous in
combination with MAO inhibitors are sedatives, tranquilizers,
antihistamines, narcotics and alcohol ) any of which can cause
hypotensive crisis (severe blood pressure drop); and amphetamines
(even diet pills), mescaline, asarone, nutmeg (active doses),
macromerine, ephedrine, oils of dill, parsley or wild fennel,
beer, wine, cocoa, aged cheese and other tyrosine)containing
foods (tyrosine is converted into tyramine by bacteria in the
bowel) ) any of which can cause hypertensive crises (severe blood
SYRIAN RUE Peganum harmala. Family Zygophyllaceae (Caltrop
Material: Seeds of woody perennial native to Middle East.
(Roots also active but seldom used.)
Usage 1 oz. seeds are thoroughly chewed and swallowed. Most
effective when combined with other psychotropic materials,
especially those containing tropanes.
Active Constituents: Harmine, harmaline and harmalol.
Effects and Contraindications: Hallucinogen; see harmine.
HARMINE 7-methoxy-1-methyl-9H-pyrido (3,4-b) indole.
Material: Indole-based alkaloid found in several plants
including Banisteriopsis caapi (from which the South American
hallucinogenic brew yage is prepared), Peganum harmala (Syrian
Unless you believe that Salvia divinorum is the old Mexica (Aztec) narcotic plant pipiltzintzintli (I don’t), the story of this fascinating mint began in the late 1930s. When R. Gordon Wasson and Albert Hoffman brought back material for Carl Epling to identify (Wasson 1962, 1963; Epling and Játiva-M 1962), they ended a search that had lasted nearly a quarter of a century. Their party traveled through Oaxaca under the auspices of a famous Mexican anthropologist, Roberto Weitlaner (an Austrian by birth), who had been guiding expeditions to Oaxaca for decades (Pompa y Pompa 1966). I’ve quoted everything relative to S. divinorum from each of the following rather rare references, translating to English where necessary.
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Salvia divinorum is a perennial labiate used for curing and divination by the Mazatec Indians of Oaxaca, Mexico. The psychotropic effects the plant produces are compared to those of the other hallucinogens employed by the Mazatecs, the morning glory, Rivea corymbosa L., Hallier f. and the psilocybin-containing mushrooms.
Next, remove the flask from the freezer, and nestle it in an ice-salt
bath. Now with stirring add a solution of 26'/i grams (17.8 ml)
trifluoroacetic anhydride in 225 ml acetonitrile. The trifluoroacetic
anhydride solution should have been previously cooled down to -20° C
in the freezer before adding. The resulting solution is stirred in the cold
and in the dark for a couple of hours, during which time the
suspended lysergic acid dissolves and forms the mixed anhydride.
Now the mixed anhydride solution is poured into 450 ml of
acetonitrile containing 23 grams diethylamine. This mixture is stirred in
the dark at room temperature for a couple of hours.
To get the product, the acetonitrile is evaporated off under a
vacuum. The residue is then dissolved in a mixture of 450 ml of
chloroform and 60 ml ice water. The chloroform layer is then
separated, and the water layer is then extracted four times with 150 ml
portions of chloroform. The combined chloroform layers are then
dried with a little sodium sulfate, and the chloroform evaporated away
under a vacuum to give a solid residue weighing about 10 grams
which is a mixture of LSD and iso-LSD. These are separated by
chromatography as described in Chapter 4, and the iso-LSD converted to
LSD as also described in that chapter.
LSD From Lysergic Acid And
The water layer from the extractions contains about 6 grams
unreacted lysergic acid. It can be recovered by acidifying with sulfuric
acid to pH 3, and filtering. This material should be purified by
recrystallization from hot water, then dried again under high vacuum.
Preparation of Trifluoroacetic Anhydride
The simplest method for making trifluoroacetic anhydride is to
dehydrate trifluoroacetic acid with phosphorus pentoxide. One is more
likely to come across a bottle of trifluoroacetic acid than the
anhydride, so knowledge of this method has a definite value.
To do this reaction, grind 25 grams phosphorous pentoxide with a
mortar and pestle, and place it in a 500 ml flask. Next add a magnetic
stirring bar, and 30 ml of trifluoroacetic acid. Rig the flask for simple
distillation using glassware that has been baked to ensure freedom
from traces of water. Flow ice water through the condenser, nestle the
receiving flask in ice, and attach a drying tube to the vacuum adapter of
Now with stirring, heat the flask with hot water — about 50-60° C.
Trifluoroacetic acid has a boiling point of 12- C, while the
anhydride has a boiling point of 40° C. The anhydride as it is formed
will boil out of the flask, to be collected in the receiving flask nestled in
ice. When no more anhydride is produced, the crude product should be
redistilled through a fractionating column. This product must then be
immediately transferred to a dried container, or kept in its receiving flask
tightly stoppered to protect from moisture. The yield is about 10 ml (15
LSD From Lysergic